Model 1 showed the age and you may intercourse-modified results

Model 1 showed the age and you may intercourse-modified results

Very first, we omitted times diagnosed with blood circulation pressure during the baseline since these users was indeed expected to alter its dietary designs immediately following perceiving exposure

Immediately following draining the bladders, the participants seated unofficially for more than five minutes. Their hypertension is counted having fun with a great calibrated mercury sphygmomanometer of the a trained fitness nursing assistant pursuing the a standardized procedure. The participants put its best sleeve inside a good cuff airbag, mentioned about step one min anywhere between tracks. We defined blood pressure levels customers who possess a mean away from SBP ? 140 mmHg, a suggest regarding DBP ? 90 mmHg, or taking antihypertensive therapy according to the assistance getting blocking and treating blood pressure for the China (2010) 23 . Diabetes and myocardial infarction were discussed based on care about-statement regarding prognosis by a health care professional in public places medical facilities over the county level. The participants must provide the new certification regarding all forms of diabetes otherwise myocardial infarction. Investigators need be certain that new patient’s prognosis regarding evidence and you will inquiry the questions ‘Has a health care provider previously provided the prognosis away from diabetes?

Have a health care provider actually ever considering you the medical diagnosis out of myocardial infarction? Therapy play with try laid out according to research by the participants’ thinking-statement, in which investigators need certainly to inquire the players the next questions: ‘Could you be delivering anti-blood pressure levels drugs? Do you make use of the oral medicine, shot off insulin, Chinese antique medication, otherwise home cures to relieve diabetes? According to assistance on prevention and you will remedy for bloodstream lipids inside the Chinese grownups (2006), players which came across one or more of the following standards: (1) TC ? 6. We together with experienced other fat reduction covariates, like overall slimming down opportunity, times, whole grain, meat, fruits, create, over loaded fatty acidic, polyunsaturated fatty acid, cereal fiber, Na, K, and you can cholesterol levels intake, given that surrogates to deal with possible weightloss confounding.

Analytical study

The latest collective mediocre consumption out of calcium supplements, magnesium, and phosphorus are determined to minimize in this-individual version meaning that gain an educated imagine of your enough time-title consumption. Person-many years of go after-right up for each and every new member had been calculated because interval between the time regarding finishing of your own baseline survey additionally the end regarding follow-right up (the brand new go out of your own history check out or perhaps the head to regarding heart attack diagnosis), almost any came first. New chance rate is determined because of the separating what amount of circumstances because of the individual-many years of follow-upwards. This new multivariate Cox proportional hazards models were utilized so you can estimate this new risk percentages (HR) and 95% count on times (95% CI) of developing heart attack according to losing weight calcium, magnesium, and you may phosphorus intake utilizing the low quartile just like the site category. Regarding Cox proportional hazards models, the new p to have development is done because of the acting the brand new median of the newest groups defined of the per quartile as an ongoing changeable.

We first performed statistical interaction tests between dietary intakes of calcium, magnesium, phosphorus, and other baseline characteristics (Table 1). We used the Kolmogorov-Sminov test to test the normality of all variables. We outlined the baseline characteristics of the participants. We used the t-test for the continuous variables with normal distribution to test for differences and trends between groups. The non-parametric test is applied to the continuous variables with non-normal distribution, and the chi-square test is used for the classified variables. Then, we categorize the three-day average intakes of calcium, magnesium, phosphorus into four levels. We constructed three sequential models to estimate the effect of calcium, magnesium, phosphorus intakes on stroke. Model 2 further added baseline sociodemographic and lifestyle factors such as urbanization index, education, household income, smoking status, alcohol intake, physical activity, BMI, hypertension, diabetes, myocardial infarction, and medication use into the multivariable analysis. Model 3 additionally adjusted for dietary factors including energy (kcal/d), whole grain (g/d), red meat (g/d), fruits (g/d), vegetables (g/d), saturated fatty acid (g/d), polyunsaturated fatty acid (g/d), cereal fiber (g/d), Na (mg/d), K (mg/d) and cholesterol (g/d) 24,25,26 . To further analyze which factors would affect the relationship between the exposure and outcome, we conducted stratified analyses by age at baseline (< 60 and ? 60 years), sex (man and woman), smoking (never and ever), drinking (never and ever), BMI (< 24, 24–28 and > 28 kg/m 2 ), hypertension, diabetes, and Myocardial infarction. The likelihood ratio test was used to assess the interactions of cross-product terms. The proportional hazards assumption for dietary calcium, magnesium, phosphorus Intakes, and other covariates was checked by Schoenfeld’s residuals, and no violation was found (P > 0.05). Besides, we performed sensitivity analyses to verify the robustness of the primary results. Second, we repeated the analysis using the non-adjusted person-time from the date of the first visit to the time of the most recent visit of stroke diagnosis or to the end of follow-up, whichever came first. Third, we included dyslipidemia as a sensitivity analysis, which confirmed the robustness of our findings to some degree. Tests for trends across dietary intake categories were conducted by modeling the median value in each quartile as a continuous variable in each model. All statistical analyses were performed with STATA version 14.0. All P-values were two-sided, and P < 0.05 was considered to statistical significance.

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